Alpha

Comics

 * Alpha: Big Time Vol 1
 * Alpha (TWD)
 * Alpha (DC Comics), a character from DC Comics
 * Alpha (Marvel Comics), a character from Marvel Comics

Fictional characters and places

 * Alpha (computer), a fictional computer in Mike Walker's radio play Alpha
 * Alpha (planet) in Isaac Asimov's novel Foundation and Earth
 * The Alpha Quadrant, one of the four Galactic Quadrants in the fictional Star Trek universe
 * Alpha 4 (Power Rangers)/Alpha 5 (Power Rangers)/Alpha 6 (Power Rangers)/Alpha 7 (Power Rangers), a "series" of characters in Power Rangers television programs
 * Alpha Legion, a Chaos Space Marines Legion from Warhammer 40,000
 * Alpha the Ultimate Mutant, a character featured in Marvel Comics
 * Moonbase Alpha, the primary setting for the television series Space: 1999

Gaming

 * Alpha (Magic: The Gathering), the first Magic: The Gathering cards set
 * Alpha (video game), a 1986 interactive fiction game by Square
 * AlphaDream, a second-party video game developer for Nintendo
 * Alpha Pokémon, Arceus from the Pokémon Universe

Literature and publications

 * Alpha (Lombard), a Franco-Belgian comics series
 * Alpha (Australian magazine), Australian men's sport magazine
 * Absolute Return + Alpha, investor magazine, incorporating a former magazine known as Alpha
 * Alpha Books, an imprint of Penguin Group (USA)
 * Alpha Girl, a 2012 Image Comics comic book series by Jean-Paul Bonjour and Jeff Roenning
 * Alpha Knightmare Frame, used by the "Irregulars" in the manga version of Code Geass: Lelouch of the Rebellion
 * The Alphas, a young-adult novel series by Lisi Harrison
 * Alpha 1 through Alpha 9, a series of nine science fiction anthologies edited by Robert Silverberg and published between 1970 and 1978. See Robert Silverberg bibliography

Television

 * Alpha TV, a Greek terrestrial channel
 * Alphas, a Syfy television series
 * "Alpha (The X-Files)," a sixth-season episode of The X-Files