Appearing in 1st story
Featured Characters:
- Spider-Man (Peter Parker) (Appears in flashback and main story)
Supporting Characters:
- Scarlet Spider (Kaine Parker) (Appears in flashback and main story)
- Web-Warriors (Appears in flashback and main story)
- [[Master Weaver (Karn)|Voice in dream]][[Category:Master Weaver (Karn)/Minor Appearances]]
- Spider-Woman (Gwen Stacy) (Appears in flashback and main story) (Impersonates Gwen Stacy)
- Parker Industries (Appears in flashback and main story)
- The Living Brain (Only in flashback)
- Anna Maria Marconi
- Horizon University
Antagonists:
- Alternate San Franciscans infected by the Carrion Virus (1st Vision)
- Max Modell (1st Vision) (Only in flashback)
- Bella Fishbach (1st Vision) (Only in flashback)
- Grady Scraps (1st Vision) (Only in flashback)
- Unidentified others (Dream)
- New U Technologies
- Gwen Stacy
- Doctor Octopus (Otto Octavius) (Appears in flashback and main story) (Possessing The Living Brain in flashback only)
- Jackal ("Miles Warren")
- Miles Warren Clones
- Rhino (Aleksei Sytsevich)
- Electro (Francine Frye)
- Lizard (Dr. Curt Connors)
- Dr. Martha Connors
- Spider-Slayer (Alistaire Smythe) (Returns)
- Jack O'Lantern (Steven Levins)
- Massacre (Marcus Lyman)
- Mirage (Desmond Charne)
- Big Man (Fred Foswell) (Returns)
- Ox (Raymond Bloch) (Returns)
- Montana (Jackson Brice)
- Spencer Smythe (Returns)
- Stilt-Man (Wilbur Day) (Returns)
- Hobgoblin (Jason Macendale) (Returns)
- Tarantula (Anton Miguel Rodriguez)
- Eduardo Lobo (Returns)
- Mysterio (Francis Klum) (Returns)
- Hitman (Burt Kenyon) (Returns)
- Kangaroo (Frank Oliver)
- Rose (Richard Fisk) (Returns)
- Green Goblin (Dr. Barton Hamilton) (Returns)
- Dr. Marla Madison-Jameson
- Spider-Woman (Mattie Franklin) (Returns) (Appears in shadow only)
- George Stacy
- Jean DeWolff (Returns)
- Prowler (Hobie Brown)
- Dr. Ashley Kafka (Returns)
- Unidentified members (Appear in shadow only)
Other Characters:
- Spider-Army (Recap)
- Spider-Man (Otto Octavius / "Peter Parker") (Recap)
- Spider-Man (Ezekiel Sims) (Recap)
- Spider-Girl (Anya Corazon) (Recap)
- Spider-Man (Peter Parker) (Recap)
- Spider-Man (Miles Morales) (Recap)
- Spider-Man (Hobie Brown) (Recap)
- Spider-Woman (Ashley Barton) (Recap)
- Spider-Monkey (Peter Parker) (Recap)
- Spider-UK (Billy Braddock) (Recap)
- Spider-Man (Miguel O'Hara) (Recap)
- Spider-Ham (Peter Porker) (Recap)
- Spider-Woman (Jessica Drew) (Recap)
- Silk (Cindy Moon) (Recap)
- Anna Maria Marconi (A.I.) (Voice only) (Only in flashback)
- Abby-L (Mentioned)
- Ben Reilly (Mentioned)
- Joyce Delaney (Mentioned)
- Spider-Skeleton (Mentioned)
- Guardian (Mentioned)
- Jack (Mentioned)
- Spidercide (Mentioned)
- Anubis (Mentioned)
- Billy Connors (Mentioned)
- Kingpin (Wilson Fisk) (Mentioned)
- Vanessa Fisk (Mentioned) (deceased)
- Fact Channel News (Mentioned)
- God (Yahweh) (Invoked)
- Jay Jameson (Mentioned)
- Alternate Parker Industries (1st Photo)
- Alternate "Peter Parker" (1st Photo)
- Alternate New U Technologies (Named only)
Races and Species:
Locations:
- Unidentified alternate reality (World destroyed by the Carrion Virus - Epicenter: Dream San Francisco) (1st Vision)
- Earth (1st Vision)
- United States of America (1st Vision)
- California (1st Vision)
- San Francisco (1st Vision)
- California (1st Vision)
- United States of America (1st Vision)
- Earth (1st Vision)
- Prime Marvel Universe
- Earth (Appears in flashback and main story)
- United States of America (Appears in flashback and main story)
- Hell (Invoked)
- Earth (Appears in flashback and main story)
- Earth-001 (Recap)
- Loomworld (Recap)
- Earth-65 (Mentioned)
Items:
- Carrion Virus
- Spider-Men's Suits (Appears in flashback and main story)
- Scarlet Spider's Suit (Appears in flashback and main story)
- Spider-Armor MK IV
- Superior Spider-Man's Suit (Only in flashback)
- Traditional Red and Blue Suit (Only in flashback)
- Ultimate Spider-Man's Suit (Only in flashback)
- Spider-Man 2099's Suit (Only in flashback)
- Dimensional Travel Watch (Dream)
- Web-Shooters (Appears in flashback and main story)
- New U Pills (Mentioned)
- Doctor Octopus' Tentacles
- Spider-Women's Suits (Only in flashback)
- Jackal's Helmet
- Rhino Armor
- Spider-Slayer Mark I
- Stilt-Man's Battlesuit
- Goblin Armor
- Prowler's Suit
Vehicles:
- Jack O'Lantern's Platform
- Goblin Glider
- Spider-Mobile (Mentioned)
Synopsis for 1st story
Doc Ock convinces Spider-Man that he is not a clone by telling him about their fight against the Inheritors and his time as Living Brain, but the Jackal sends him away telling him that he wants him in the lab not to fight Spider-Man after which he takes him around the New U with Gwen. Spider-Man discovers that the Jackal has revived many of his deceased enemies, as well as Captain Stacy, Jean DeWolff, Prowler, and Ashley Kafka. George however declares that Gwen is not his daughter, and in fact the blonde turns out to be the Gwen of Earth-65 who runs away with Spider-Man. Earth-616's Gwen was kidnapped by Kaine who took her to Horizon University so she can have her meds, saying that if she doesn't take the pill she will turn into a Zombie capable of infecting everyone, which would lead to the end of the world. When Anna Maria asks him why he didn't ask for Peter's assistance, Kaine replies that in other dimensions, the collaboration between Parker Industries and New U has destroyed the world.
Solicit Synopsis
• The surprises keep coming in the SPIDER-MAN EVENT OF THE YEAR!
• Doc Ock is back and it’s time for him and the Amazing Spider-Man to throw down!
• What lurks in the Underground?!Trivia
- At one point, Jackal references Yoda.