Mastermind, in comics, may refer to:
- Mastermind, the first Marvel Comics supervillain to use the title.
- Mastermind, Wyngarde's daughter
- Lady Mastermind (Regan Wyngarde), Wyngarde's other daughter
- Mastermind, an enemy of Captain Britain
- Master Mind Excello, a Golden Age superhero
- Amadeus Cho, who also operates under the name "Mastermind Excello"
- Master Mind, a British comic strip
- Mastermind (DC Comics), an enemy of the Challengers of the Unknown.
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