Medusa is one of the three Gorgons in Greek mythology.
Medusa may also refer to:
- Medusa, a novel by Hammond Innes
- Medusa, a novel by Thomas Thiemeyer
- Medusa (Cussler novel), a novel by Clive Cussler and Paul Kemprecos
- Medusa (Dibdin novel), a novel by Michael Dibdin
- Medusa, a Soul Eater character
- Medusa, a Kamen Rider Wizard character
- Medusa, a military unit in the Jason Bourne novel series
- Medusa, a planet in the TV series Star Maidens
- Madame Medusa, a character in The Rescuers
- Medusae, an alien race in the novel The Legion of Space
- Medusa, an antagonist in the Japanese manga Rosario + Vampire
- Rider, a Fate/stay night character
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